Remote ischemic post‑conditioning protects against myocardial ischemia/reperfusion injury by inhibiting the Rho‑kinase signaling pathway
نویسندگان
چکیده
منابع مشابه
Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway.
BACKGROUND AND PURPOSE Remote ischemic postconditoning, a phenomenon in which brief ischemic stimuli of 1 organ protect another organ against an ischemic insult, has been demonstrated to protect the myocardium and adult brain in animal models. However, mediators of the protection and underlying mechanisms remain to be elucidated. In the present study, we tested the hypothesis that remote limb i...
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AIMS Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion injury. We propose that IPostC confers its infarct-sparing effect via activation of the newly described prosurvival Survivor Activating Factor Enhancement (SAFE) pathway, which involves the activation of the cytokine tumour necrosis factor al...
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BACKGROUND We and others have reported that rapid ischemic postconditioning, interrupting early reperfusion after stroke, reduces infarction in rats. However, its extremely short therapeutic time windows, from a few seconds to minutes after reperfusion, may hinder its clinical translation. Thus, in this study we explored if delayed postconditioning, which is conducted a few hours after reperfus...
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Purpose: To investigate the effect and possible mechanism of combination of apigenin and ischemic post conditioning on renal ischemia-reperfusion injury in rats. Materials and methods: Fifty rats were randomly separated into 5 groups: (1) sham-operation groups: a midline laparotomy was performed only; (2) I/R group: rats were underwent 45 min of renal ischemia; (3) apigenin group: rats was subj...
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It is known that dynamin-related protein 1 (Drp1)-mediated mitochondrial fission plays an important role in ischemic injury of myocardial infarction (MI). Apelin, an endogenous ligand for Apelin receptor, acts as a key modulator of cardiovascular diseases. Here, we examined the effects of Apelin on MI injury and underlying mechanisms. Adult male C57BL/6J mice were treated with Apelin for 4 week...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2019
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2019.8176